Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within PARK16 locus has been reported to be associated with disease. Cognitive impairment non-motor symptoms considered a challenge in patients. This study aimed investigate association rs11240569 polymorphism; synonymous coding variant SLC41A1 patients addition assessment cognitive those Results In case -control study, single nucleotide polymorphisms SLC41A1, genes were genotyped 48 controls. Motor performance Parkinson's assessed using Movement Disorder Society-Sponsored Revision Unified Disease Rating Scale (MDS-UPDRS) . The genotype allele frequencies compared two groups revealed no significant differences control for gene P value .523 .54, respectively. Cognition was evaluated showed mean ± standard deviation (SD) WAIS score PD 80.4 9.13 range from 61 105, MMSE SD 21.96 3.8. Conclusion Genetic testing present polymorphism distributions alleles genotypes cases group, large proportion strong correlation motor progression.